Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SI | P14410 | 2/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749257 | 1.00 | MGAM (0.43) | MGAMGAASIMGAM2TRPA1 | |
| SCHEMBL27661014 | 0.82 | MGAM (0.41) | MGAMGAASIMGAM2 | |
| SCHEMBL11771658 | 0.79 | TRPA1 (0.42) | MGAMGAASIMGAM2TRPA1 | |
| SCHEMBL6444996 | 0.79 | MGAM (0.46) | MGAMGAASIMGAM2 | |
| SCHEMBL6445001 | 0.79 | MGAM (0.46) | MGAMGAASIMGAM2 | |
| SCHEMBL5227698 | 0.79 | MGAM (0.46) | MGAMGAASIMGAM2 | |
| SCHEMBL7195463 | 0.79 | — | — | |
| SCHEMBL11364592 | 0.79 | — | — | |
| SCHEMBL7862517 | 0.79 | — | — | |
| SCHEMBL28125722 | 0.79 | MGAM (0.50) | MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102947311-B | 3-oxo-3, 9-dihydro-1H-benzopyrano [2,3-C ] pyrroles as glucokinase activators | HOFFMAN-LA ROCHE LTD. (CH) | 2015-11-25 | — | — | CN | disclosed |
| CN-102947311-A | 3-oxo-3, 9-dihydro-1H-benzopyrano [2,3-C ] pyrroles as glucokinase activators | HOFFMANN LA ROCHE | 2013-02-27 | — | — | CN | disclosed |