Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.61 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.57 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.57 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13406708 | 0.83 | ALDH1A1 (0.63) | POLBMEN1KMT2ASLC6A7TSHR | |
| SCHEMBL10721777 | 0.82 | MEN1 (0.87) | POLBMEN1KMT2ASLC6A7TSHR | |
| SCHEMBL15302690 | 0.81 | MEN1 (0.58) | POLBMEN1KMT2ASLC6A7PRKAA2 | |
| SCHEMBL518526 | 0.81 | PRKAA2 (0.71) | MEN1KMT2APRKAA2PRKAB2PRKAG1 | |
| SCHEMBL8595777 | 0.78 | POLB (0.87) | POLBMEN1KMT2ASLC6A7TSHR | |
| SCHEMBL21987023 | 0.77 | MAPT (0.69) | POLBMEN1KMT2ASLC6A7TSHR | |
| SCHEMBL519229 | 0.76 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL8161635 | 0.76 | SLC6A7 (1.00) | POLBMEN1KMT2ASLC6A7TSHR | |
| SCHEMBL27927256 | 0.75 | TSHR (0.66) | POLBMEN1KMT2ASLC6A7TSHR | |
| SCHEMBL10721885 | 0.75 | POLB (0.74) | POLBMEN1KMT2ASLC6A7TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201267-A | AMPK-activating heterocyclic compounds and methods of use thereof | RIGEL PHARMACEUTICALS INC | 2013-07-10 | — | — | CN | claimed |