Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960762 | 0.84 | SOS1 (0.54) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL20626535 | 0.81 | SOS1 (0.51) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL21218127 | 0.79 | GNAI3 (0.51) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| Butane SCHEMBL27323486 | 0.78 | GNAI3 (0.59) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL20648825 | 0.77 | GNAI3 (0.58) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL20039920 | 0.76 | GNAI3 (0.49) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL22415116 | 0.76 | GNAI3 (0.56) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL19560897 | 0.76 | GNAI3 (0.61) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL8851791 | 0.74 | GNAI3 (0.50) | SOS1GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL19604920 | 0.74 | GNAI3 (0.64) | SOS1GNAI3GNAO1GNAI1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201267-A | AMPK-activating heterocyclic compounds and methods of use thereof | RIGEL PHARMACEUTICALS INC | 2013-07-10 | — | — | CN | disclosed |