Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25867869 | 0.78 | HRH3 (0.50) | HRH1L3MBTL1HRH3ALDH1A1LMNA | |
| SCHEMBL20825349 | 0.75 | HRH1 (0.47) | HRH1L3MBTL1HRH3ALDH1A1LMNA | |
| SCHEMBL29485678 | 0.75 | HRH1 (0.73) | HRH1HRH3ALDH1A1LMNATAAR1 | |
| SCHEMBL230753 | 0.75 | HRH1 (0.73) | HRH1HRH3ALDH1A1LMNATAAR1 | |
| Bromide SCHEMBL28641396 | 0.73 | HRH1 (0.70) | HRH1HRH3ALDH1A1LMNATAAR1 | |
| SCHEMBL29806495 | 0.71 | — | — | |
| SCHEMBL12801 | 0.71 | — | — | |
| SCHEMBL56199 | 0.71 | — | — | |
| SCHEMBL726512 | 0.71 | HRH1 (0.76) | HRH1HRH3ALDH1A1LMNATAAR1 | |
| SCHEMBL29485637 | 0.71 | HRH1 (0.69) | HRH1HRH3ALDH1A1LMNATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103180296-A | Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer | AMGEN INC | 2013-06-26 | — | — | CN | disclosed |