Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | TYK2 | P29597 | 7/20 | 0.40 |
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28805477 | 0.90 | JAK2 (0.42) | AXLJAK2TYK2JAK1JAK3 | |
| SCHEMBL30891589 | 0.87 | GFER (0.39) | AXLJAK2TYK2JAK1JAK3 | |
| SCHEMBL27917289 | 0.86 | JAK2 (0.44) | JAK2TYK2JAK1JAK3FLT3 | |
| SCHEMBL28807355 | 0.85 | JAK2 (0.43) | JAK2TYK2JAK1JAK3FLT3 | |
| SCHEMBL22544592 | 0.82 | CDK4 (0.49) | AXLJAK2TYK2JAK1JAK3 | |
| SCHEMBL29754277 | 0.82 | CDK4 (0.49) | AXLJAK2TYK2JAK1JAK3 | |
| SCHEMBL22546075 | 0.81 | IGF1R (0.46) | JAK2TYK2CDK4CDK6KCNH2 | |
| SCHEMBL29754173 | 0.81 | IGF1R (0.46) | JAK2TYK2CDK4CDK6KCNH2 | |
| SCHEMBL22544822 | 0.80 | IGF1R (0.53) | FLT4KCNH2CDK2 | |
| SCHEMBL22544564 | 0.80 | CDK4 (0.54) | AXLJAK2JAK1JAK3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | claimed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |