Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 5/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27917420 | 0.87 | AXL (0.40) | AXLJAK3JAK2TYK2JAK1 | |
| SCHEMBL30891576 | 0.87 | JAK3 (0.36) | AXLBTKIGF1RJAK3JAK2 | |
| SCHEMBL27275338 | 0.87 | IGF1R (0.46) | BTKIGF1RJAK3JAK2JAK1 | |
| SCHEMBL30956580 | 0.87 | CPT1A (0.39) | IGF1RJAK3JAK2JAK1NPSR1 | |
| SCHEMBL27278163 | 0.84 | MYLK4 (0.43) | AXLBTKIGF1RJAK3JAK2 | |
| SCHEMBL30956382 | 0.83 | JAK2 (0.53) | JAK3JAK2TYK2JAK1CDK6 | |
| SCHEMBL30956584 | 0.82 | JAK2 (0.41) | IGF1RJAK3JAK2TYK2JAK1 | |
| SCHEMBL28720843 | 0.81 | HDAC3 (0.39) | AXLBTKJAK3JAK2JAK1 | |
| SCHEMBL30956471 | 0.79 | IGF1R (0.41) | BTKIGF1RJAK3JAK2JAK1 | |
| SCHEMBL28805477 | 0.78 | JAK2 (0.42) | AXLJAK3JAK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118702683-A | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-113993861-B | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-05-14 | — | — | CN | disclosed |