Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.37 |
| ▸ | UGCG | Q16739 | 2/20 | 0.37 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28808912 | 0.94 | TAS1R3 (0.42) | TAS1R3TAS1R1JAK2LNPEPS1PR1 | |
| SCHEMBL27923595 | 0.92 | TAS1R3 (0.41) | TAS1R3TAS1R1JAK2LNPEPSIRT2 | |
| SCHEMBL27923593 | 0.88 | JAK2 (0.43) | TAS1R3TAS1R1JAK2LNPEPSIRT2 | |
| SCHEMBL28808910 | 0.85 | TAS1R3 (0.42) | TAS1R3TAS1R1JAK2LNPEPS1PR1 | |
| SCHEMBL27923613 | 0.85 | JAK2 (0.41) | JAK2LNPEPS1PR1UGCG | |
| SCHEMBL28808909 | 0.81 | TAS1R3 (0.46) | TAS1R3TAS1R1JAK2LNPEPS1PR1 | |
| SCHEMBL1375523 | 0.79 | S1PR1 (0.60) | TAS1R3TAS1R1JAK2SIRT2SIRT1 | |
| SCHEMBL27942618 | 0.76 | UGCG (0.41) | S1PR1UGCGCTSSBCL2L1 | |
| SCHEMBL27923611 | 0.76 | JAK2 (0.44) | JAK2LNPEPS1PR1UGCGMAPK14 | |
| SCHEMBL27923608 | 0.76 | S1PR1 (0.47) | S1PR1UGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102245174-B | Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents | EXELIXIS INC | 2013-11-06 | — | — | CN | disclosed |