Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.44 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27923593 | 0.93 | JAK2 (0.43) | TAS1R3TAS1R1PADI4PADI2JAK2 | |
| SCHEMBL28808910 | 0.91 | TAS1R3 (0.42) | TAS1R3TAS1R1PADI4PADI2JAK2 | |
| SCHEMBL28808912 | 0.88 | TAS1R3 (0.42) | TAS1R3TAS1R1PADI4PADI2JAK2 | |
| SCHEMBL1371827 | 0.84 | S1PR1 (0.59) | TAS1R3TAS1R1PADI4PADI2JAK2 | |
| SCHEMBL27923595 | 0.84 | TAS1R3 (0.41) | TAS1R3TAS1R1PADI4PADI2JAK2 | |
| SCHEMBL27923609 | 0.83 | JAK2 (0.44) | JAK2S1PR1LNPEPMAPK14HDAC3 | |
| SCHEMBL27923596 | 0.81 | TAS1R3 (0.39) | TAS1R3TAS1R1PADI4PADI2JAK2 | |
| SCHEMBL1375523 | 0.77 | S1PR1 (0.60) | TAS1R3TAS1R1JAK2S1PR1 | |
| SCHEMBL27942617 | 0.75 | UGCG (0.43) | JAK2S1PR1 | |
| SCHEMBL27923611 | 0.74 | JAK2 (0.44) | JAK2S1PR1LNPEPMAPK14HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102245174-B | Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents | EXELIXIS INC | 2013-11-06 | — | — | CN | disclosed |