Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943243 | 0.91 | GRM2 (0.59) | GRM2ALOX5KCNH2 | |
| SCHEMBL755743 | 0.90 | GRM2 (0.72) | GRM2ALOX5KCNH2 | |
| SCHEMBL755742 | 0.90 | GRM2 (0.72) | GRM2ALOX5KCNH2 | |
| SCHEMBL756231 | 0.83 | GRM2 (0.83) | GRM2 | |
| SCHEMBL756410 | 0.79 | GRM2 (0.53) | GRM2ALOX5KCNH2 | |
| SCHEMBL756603 | 0.76 | GRM2 (0.79) | GRM2ALOX5KCNH2 | |
| SCHEMBL756602 | 0.76 | GRM2 (0.79) | GRM2ALOX5KCNH2 | |
| SCHEMBL758501 | 0.75 | GRM2 (0.77) | GRM2ALOX5KCNH2 | |
| SCHEMBL756794 | 0.75 | GRM2 (0.79) | GRM2ALOX5KCNH2 | |
| SCHEMBL756214 | 0.75 | GRM2 (0.79) | GRM2ALOX5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101657443-B | [1,2,3] triazole-substituted quinolines and coumarins as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA LTD | 2013-10-23 | — | — | CN | disclosed |