Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28069879 | 0.87 | EGLN1 (0.51) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL14957514 | 0.87 | ALDH1A1 (0.47) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL12503112 | 0.79 | MAPT (0.48) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL8175132 | 0.78 | LMNA (0.56) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL30575755 | 0.77 | PDE10A (0.52) | EGLN1TP53KDM4CMEN1KMT2A | |
| SCHEMBL28152715 | 0.76 | MEN1 (0.46) | EGLN1TP53KDM4CMEN1KMT2A | |
| SCHEMBL12503041 | 0.75 | MAPT (0.51) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL8331084 | 0.75 | LMNA (0.57) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL17801486 | 0.74 | HDAC3 (0.59) | EGLN1TP53HDAC3HDAC1HDAC6 | |
| SCHEMBL30095490 | 0.74 | HDAC3 (0.59) | EGLN1TP53HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103119043-A | Fused heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL | 2013-05-22 | — | — | CN | disclosed |