Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28246496 | 0.82 | MCL1 (0.54) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL30622502 | 0.81 | MCL1 (0.53) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL5387046 | 0.81 | MCL1 (0.53) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL1664172 | 0.79 | MCL1 (0.55) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL3785550 | 0.78 | MCL1 (0.51) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL5981752 | 0.78 | MCL1 (0.57) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL6179658 | 0.77 | HDAC1 (0.55) | MCL1HPGDPOLBNR1H4EPHX2 | |
| SCHEMBL8553607 | 0.77 | B3GNT2 (0.50) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL1664006 | 0.77 | MCL1 (0.59) | MCL1PLA2G4AKMOKDM4EALDH1A1 | |
| SCHEMBL3351795 | 0.76 | MCL1 (0.61) | MCL1PLA2G4AKMOKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | claimed |
| CN-109121414-B | Benzopyrazole compounds and analogs thereof | 拜奥克里斯特制药公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |