Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791147 | 0.88 | NAMPT (0.60) | NAMPTRAB9AROCK2ROCK1LMNA | |
| SCHEMBL2792843 | 0.86 | ROCK2 (0.52) | NAMPTRAB9AROCK2ROCK1JAK2 | |
| SCHEMBL2791644 | 0.85 | NAMPT (0.64) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| SCHEMBL2795774 | 0.83 | POLB (0.63) | NAMPTROCK2ROCK1JAK2TYK2 | |
| SCHEMBL2794381 | 0.82 | ROCK2 (0.64) | NAMPTRAB9AROCK2ROCK1JAK2 | |
| SCHEMBL2824904 | 0.81 | DNMT3B (0.56) | NAMPTRAB9AROCK2ROCK1LMNA | |
| SCHEMBL2795335 | 0.81 | ROCK2 (0.62) | NAMPTRAB9AROCK2ROCK1JAK2 | |
| SCHEMBL2791632 | 0.81 | NAMPT (0.63) | NAMPTROCK2ROCK1JAK2TYK2 | |
| SCHEMBL2794980 | 0.81 | ROCK2 (0.68) | NAMPTROCK2ROCK1LMNAJAK2 | |
| SCHEMBL2791347 | 0.81 | NAMPT (0.64) | NAMPTROCK2ROCK1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2010-07-01 | — | — | US | disclosed |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | NAMPT 1420/4885RAB9A 2781/4885ROCK2 528/4885 |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | NAMPT 1420/4885RAB9A 2781/4885ROCK2 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.