Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 15/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161941 | 0.88 | L3MBTL1 (0.60) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL10264809 | 0.76 | L3MBTL1 (0.53) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL1912421 | 0.76 | RAF1 (0.51) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL24212419 | 0.75 | L3MBTL1 (0.46) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL161668 | 0.74 | RAF1 (0.56) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL9965178 | 0.73 | RAF1 (0.51) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL173108 | 0.73 | RAF1 (0.56) | L3MBTL1MAPTRAF1MAPK14MAPK13 | |
| SCHEMBL24212638 | 0.72 | MAPT (0.44) | L3MBTL1MAPTPKMRAF1MAPK14 | |
| SCHEMBL14467713 | 0.72 | RAF1 (0.60) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL15662368 | 0.72 | L3MBTL1 (0.49) | L3MBTL1MAPTPKMRAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201277-B | Pyridazinone, its preparation method and using method | GILEAD CONNECTICUT, INC. (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-104812746-A | Bruton's tyrosine kinase inhibitors | HOFFMANN LA ROCHE | 2015-07-29 | — | — | CN | disclosed |
| CN-104662024-A | Tyrosine Kinase Inhibitors | HOFFMANN LA ROCHE | 2015-05-27 | — | — | CN | disclosed |
| CN-103201277-A | Pyridazinones, method of making, and method of use thereof | GILEAD CONNECTICUT INC | 2013-07-10 | — | — | CN | disclosed |
| CN-103189369-A | Pyridone/pyrazinones, methods of making, and methods of use thereof | GILEAD CONNECTICUT INC | 2013-07-03 | — | — | CN | disclosed |