Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16462691 | 0.83 | MKNK1 (0.50) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL28785366 | 0.83 | MKNK1 (0.53) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL28784266 | 0.82 | BCAT2 (0.44) | — | |
| SCHEMBL22468503 | 0.82 | MKNK1 (0.62) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL6237458 | 0.77 | MKNK1 (0.58) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL6237449 | 0.77 | MKNK1 (0.62) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL27880990 | 0.76 | MKNK1 (0.58) | MKNK1MKNK2CYP1A2CYP3A4SIRT3 | |
| SCHEMBL17067114 | 0.75 | MKNK1 (0.67) | MKNK1MKNK2 | |
| SCHEMBL30702229 | 0.74 | MKNK1 (0.59) | MKNK1MKNK2LMNACYP1A2CYP3A4 | |
| SCHEMBL30702237 | 0.74 | MKNK1 (0.59) | MKNK1MKNK2LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903362-B | Tetrazole-substituted arylamide derivatives and their use as P2X3 and/or P2X2/3 purinergic receptor antagonists | HOFFMANN LA ROCHE | 2013-07-17 | — | — | CN | disclosed |