Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.53 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16463190 | 0.84 | MKNK1 (0.47) | MKNK1MKNK2CFTRMAPK8MAPK10 | |
| SCHEMBL6173691 | 0.84 | FABP4 (0.45) | SCN9A | |
| SCHEMBL29427280 | 0.83 | SCN5A (0.49) | MKNK1MKNK2CFTRMAPK8MAPK10 | |
| SCHEMBL27928558 | 0.83 | MKNK1 (0.57) | MKNK1MKNK2BTKCYP3A4CYP2C19 | |
| SCHEMBL16463132 | 0.82 | MKNK1 (0.48) | MKNK1MKNK2CFTRMAPK8MAPK10 | |
| SCHEMBL28225832 | 0.80 | CFTR (0.46) | MKNK1MKNK2CFTRMAPK8MAPK10 | |
| SCHEMBL4442762 | 0.77 | MKNK1 (0.66) | MKNK1MKNK2CFTRMAPK8MAPK10 | |
| SCHEMBL2421547 | 0.77 | PTGS2 (0.44) | CFTRLMNASCN5ASCN9AERN1 | |
| SCHEMBL22468503 | 0.76 | MKNK1 (0.62) | MKNK1MKNK2BTKCYP3A4CYP2C19 | |
| SCHEMBL28225836 | 0.76 | CFTR (0.47) | MKNK1MKNK2CFTRMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101855208-A | 5, 6-diaryl pyridines substituted in the 2-and 3-position, their preparation and their therapeutic use | SANOFI AVENTIS | 2010-10-06 | — | — | CN | disclosed |