Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.70 |
| ▸ | PRKG1 | Q13976 | 8/20 | 0.70 |
| ▸ | GSK3B | P49841 | 7/20 | 0.70 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.70 |
| ▸ | PRKG2 | Q13237 | 7/20 | 0.70 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.70 |
| ▸ | CDK2 | P24941 | 6/20 | 0.70 |
| ▸ | GSK3A | P49840 | 6/20 | 0.70 |
| ▸ | SGK2 | Q9HBY8 | 6/20 | 0.70 |
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.70 |
| ▸ | PRKACA | P17612 | 5/20 | 0.70 |
| ▸ | CDK1 | P06493 | 5/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.70 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.70 |
| ▸ | AKT1 | P31749 | 5/20 | 0.70 |
| ▸ | PRKX | P51817 | 4/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27928751 | 0.85 | ROCK2 (0.77) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL3109564 | 0.84 | ROCK1 (0.77) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL3109180 | 0.83 | ROCK2 (0.75) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL3103857 | 0.83 | ROCK1 (0.75) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL3109453 | 0.83 | ROCK1 (0.75) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL3093010 | 0.82 | ROCK1 (1.00) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL3109948 | 0.82 | ROCK1 (1.00) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL506306 | 0.81 | ALDH1A1 (0.66) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL506386 | 0.81 | ALDH1A1 (0.66) | ROCK2ROCK1PRKG1GSK3BPRKCD | |
| SCHEMBL506305 | 0.81 | ALDH1A1 (0.66) | ROCK2ROCK1PRKG1GSK3BPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903349-B | 4- (4-pyridinyl) -benzamides and their use as ROCK activity modulators | ABBOTT GMBH & CO KG | 2014-01-08 | — | — | CN | claimed |
| CN-103896831-A | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators | ABBVIE DEUTSCHLAND | 2014-07-02 | — | — | CN | disclosed |