Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31517450 | 0.80 | KDM4E (0.46) | KMT2AKDM4EALDH1A1NPC1GLA | |
| SCHEMBL24921154 | 0.80 | KDM4E (0.46) | KMT2AKDM4EALDH1A1NPC1GLA | |
| SCHEMBL2732399 | 0.75 | KCNJ1 (0.47) | KMT2AMEN1 | |
| SCHEMBL199306 | 0.75 | ALDH1A1 (0.65) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL2518688 | 0.75 | KDM4E (0.46) | LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL6662960 | 0.74 | ALDH1A1 (0.38) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL4538030 | 0.73 | IRAK4 (0.49) | LMNAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL28812535 | 0.73 | ALDH1A1 (0.63) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL31519065 | 0.73 | ALDH1A1 (0.63) | LMNAKMT2AKDM4EALDH1A1NPC1 | |
| SCHEMBL19743952 | 0.72 | HTR1A (0.49) | LMNAKDM4EALDH1A1NPC1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201261-A | Lactam derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2013-07-10 | — | — | CN | disclosed |