Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.53 |
| ▸ | NAMPT | P43490 | 11/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792872 | 0.93 | MTOR (0.50) | HIF1AEPAS1NAMPTROCK2ROCK1 | |
| SCHEMBL2794103 | 0.91 | ROCK2 (0.57) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| SCHEMBL13230434 | 0.91 | NAMPT (0.60) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| SCHEMBL13230439 | 0.91 | NAMPT (0.60) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| SCHEMBL2795349 | 0.91 | NAMPT (0.60) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| SCHEMBL2795269 | 0.90 | MLYCD (0.50) | HIF1AEPAS1NAMPTROCK2ROCK1 | |
| SCHEMBL2794919 | 0.90 | HIF1A (0.52) | HIF1AEPAS1NAMPTROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL2790960 | 0.90 | NAMPT (0.59) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27719878 | 0.90 | NAMPT (0.59) | NAMPTROCK2ROCK1KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2791710 | 0.90 | NAMPT (0.59) | NAMPTROCK2ROCK1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2010-07-01 | — | — | US | disclosed |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | HIF1A 1857/4885EPAS1 2609/4885NAMPT 1420/4885 |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | HIF1A 1857/4885EPAS1 2609/4885NAMPT 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.