Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.49 |
| ▸ | RXRB | P28702 | 5/20 | 0.49 |
| ▸ | RXRG | P48443 | 5/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 5/20 | 0.42 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3102384 | 0.82 | AR (0.42) | FFAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3903260 | 0.81 | RXRA (0.52) | RXRARXRBRXRGFFAR1PSEN1 | |
| SCHEMBL3903168 | 0.78 | ALDH1A1 (0.50) | RXRARXRBFFAR1PSEN1PSEN2 | |
| SCHEMBL27748366 | 0.76 | CYP1A1 (0.39) | FFAR1ERAP1PPARDPPARAPPARG | |
| SCHEMBL5860624 | 0.75 | PPARD (0.72) | PPARDPPARAPPARG | |
| SCHEMBL5861681 | 0.75 | PPARD (0.72) | PPARDPPARAPPARG | |
| SCHEMBL3906708 | 0.75 | PPARD (0.64) | PPARDPPARAPPARG | |
| SCHEMBL3804094 | 0.74 | PPARD (0.66) | RXRARXRBRXRGFFAR1PSEN1 | |
| SCHEMBL3901311 | 0.74 | FFAR1 (0.43) | RXRARXRBRXRGFFAR1PSEN1 | |
| SCHEMBL3915373 | 0.74 | FFAR1 (0.56) | RXRARXRBRXRGFFAR1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479008-B | PPAR-delta agonist benzazepine-oxyacetic acid derivatives for raising HDL-C, lowering LDL-C and lowering cholesterol | JANSSEN PHARMACEUTICA NV | 2013-07-17 | — | — | CN | disclosed |