Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30073089 | 1.00 | KDM4E (0.53) | KDM4EMEN1KMT2ALTA4HMAPK14 | |
| SCHEMBL14361190 | 0.86 | LTA4H (0.57) | KDM4EMEN1KMT2ALTA4HMAPK14 | |
| SCHEMBL27929011 | 0.80 | MEN1 (0.46) | KDM4EMEN1KMT2AMAP4K4SMN1; SMN2 | |
| SCHEMBL1340917 | 0.79 | HTR1A (0.52) | KDM4EMEN1KMT2AMAP4K4SMN1; SMN2 | |
| SCHEMBL11543904 | 0.78 | KDM4E (0.53) | KDM4EMEN1KMT2AMAPTHTR1A | |
| SCHEMBL2657071 | 0.78 | NPC1 (0.50) | KMT2ALTA4HMAPK14MAP4K4SMN1; SMN2 | |
| SCHEMBL1327928 | 0.77 | LTA4H (0.58) | MEN1KMT2ALTA4HMAPK14SMN1; SMN2 | |
| SCHEMBL30773497 | 0.77 | HTR1A (0.55) | KDM4EMEN1KMT2AHTR1ASLC6A2 | |
| SCHEMBL2389927 | 0.77 | HTR1A (0.55) | KDM4EMEN1KMT2AHTR1ASLC6A2 | |
| SCHEMBL28930254 | 0.76 | LTA4H (0.52) | KDM4EMEN1KMT2ALTA4HMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101868459-B | Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as glucokinase activators for treatment of diabetes mellitus | ARRAY BIOPHARMA INC | 2013-12-18 | — | — | CN | disclosed |