SCHEMBL27935641

SCHEMBL27935641

COc1cc(OC)cc(-c2c(N)ccc(-c3ccc(N)cc3)c2-c2cc(OC)cc(OC)c2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 4/20 0.45
ABCB1 P08183 4/20 0.45
BCR P11274 4/20 0.45
CYP19A1 P11511 2/20 0.44
NQO2 P16083 1/20 0.44
TDP1 Q9NUW8 3/20 0.42
MAPK1 P28482 1/20 0.42
CYP3A4 P08684 5/20 0.41
ALDH1A1 P00352 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
APP P05067 2/20 0.40
HSD17B10 Q99714 2/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
TP53 P04637 1/20 0.38
HPGD P15428 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38
NFKB2 Q00653 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL415915 0.87 TDP1 (0.55) ABL1ABCB1BCRTDP1MAPK1
SCHEMBL29756035 0.78 TDP1 (0.46) TDP1CYP3A4ALDH1A1SMN1; SMN2APP
SCHEMBL18889618 0.78 TDP1 (0.46) TDP1CYP3A4ALDH1A1SMN1; SMN2APP
SCHEMBL3468830 0.78 ACHE (0.50) TDP1CYP3A4ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL24560 0.75 TDP1 (0.46) TDP1MAPK1CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL6011385 0.74 ABL1 (0.47) ABL1ABCB1BCRCYP19A1NQO2
SCHEMBL6572399 0.74 ABL1 (0.47) ABL1ABCB1BCRCYP19A1NQO2
SCHEMBL3789140 0.74 TDP1 (0.56) ABL1ABCB1BCRTDP1MAPK1
SCHEMBL3794745 0.74 TDP1 (0.56) TDP1MAPK1CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL9330647 0.72 TDP1 (0.48) TDP1CYP3A4ALDH1A1SMN1; SMN2APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102557930-B Biphenyl molecular glass and preparation method thereof UNIV NANJING AERONAUTICS 2014-01-29 CN disclosed