Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 9/20 | 0.37 |
| ▸ | PPARA | Q07869 | 8/20 | 0.37 |
| ▸ | PPARD | Q03181 | 7/20 | 0.36 |
| ▸ | LDHA | P00338 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28810374 | 0.91 | MAPT (0.37) | PPARGPPARAPPARDMAPTKDM4E | |
| SCHEMBL28809330 | 0.86 | PPARG (0.37) | PPARGPPARAPPARDTP53MAPT | |
| SCHEMBL28807365 | 0.86 | PTGER1 (0.40) | PTGER1LDHACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27936024 | 0.84 | PPARG (0.39) | PPARGPPARAPPARD | |
| SCHEMBL27936046 | 0.84 | PPARG (0.37) | PPARGPPARAPPARDTP53MAPT | |
| SCHEMBL27950252 | 0.84 | PPARG (0.38) | PPARGPPARAPPARD | |
| SCHEMBL12096905 | 0.83 | PPARG (0.50) | PTGER1PPARGPPARAPPARDLDHA | |
| SCHEMBL28807362 | 0.83 | PPARG (0.39) | PPARGPPARAPPARDTP53MAPT | |
| SCHEMBL27936025 | 0.83 | PPARG (0.36) | PPARGPPARAPPARDP4HBTP53 | |
| SCHEMBL27950238 | 0.82 | POLB (0.44) | PPARGPPARAPPARDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |