Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28947331 | 0.92 | MAPT (0.36) | PTGER1KDM4E | |
| SCHEMBL27936035 | 0.86 | PTGER1 (0.39) | PTGER1CYP2C9CYP2C19CYP1A2LDHA | |
| SCHEMBL27936040 | 0.84 | ITK (0.33) | CYP2C9CYP2C19CYP3A4CYP2D6HTT | |
| SCHEMBL27950237 | 0.84 | MEN1 (0.37) | CYP2C9CYP2C19CYP3A4CYP2D6HTT | |
| SCHEMBL12096702 | 0.84 | PTGER1 (0.43) | PTGER1CYP2C9CYP2C19CYP1A2LDHA | |
| SCHEMBL27936131 | 0.84 | MRGPRX4 (0.37) | CYP2C9CYP2C19CYP3A4CYP2D6HTT | |
| SCHEMBL28947517 | 0.80 | HTT (0.33) | CYP2C9CYP2C19CYP3A4CYP2D6HTT | |
| SCHEMBL28810374 | 0.79 | MAPT (0.37) | KDM4E | |
| SCHEMBL27936061 | 0.77 | MAPT (0.36) | CYP2C9CYP2C19CYP1A2KDM4E | |
| SCHEMBL28809330 | 0.76 | PPARG (0.37) | ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |