SCHEMBL27939752

SCHEMBL27939752

Nc1ccc2ccn(-c3cccc(O)c3)c2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.44
ALDH1A1 P00352 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CA14 Q9ULX7 1/20 0.44
CDC7 O00311 4/20 0.43
CDK2 P24941 4/20 0.43
FGFR1 P11362 1/20 0.41
F2 P00734 2/20 0.40
F10 P00742 2/20 0.40
PRSS1 P07477 2/20 0.40
ROCK2 O75116 1/20 0.39
PIM1 P11309 1/20 0.39
PIM3 Q86V86 1/20 0.39
OPRD1 P41143 1/20 0.38
PIK3CG P48736 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15712770 0.82 SMN1; SMN2 (0.55) ALDH1A1TDP1CDC7CDK2FGFR1
SCHEMBL28942970 0.78 TSHR (0.49) ALDH1A1TDP1CDC7CDK2SMN1; SMN2
SCHEMBL30364596 0.78 TSHR (0.49) ALDH1A1TDP1CDC7CDK2SMN1; SMN2
SCHEMBL27939704 0.76 ALDH1A1 (0.51) ALDH1A1CDC7FGFR1SMN1; SMN2MAPT
SCHEMBL16719968 0.74 FGFR1 (0.40) CA12ALDH1A1CA2CA9CA14
SCHEMBL31413331 0.73 PRKCI (0.42) ALDH1A1CDC7CDK2MAPTMAP3K14
SCHEMBL21925193 0.73 PRKCI (0.42) ALDH1A1CDC7CDK2MAPTMAP3K14
SCHEMBL28616645 0.71 PRKCI (0.40) ALDH1A1CDC7CDK2F2F10
SCHEMBL16719724 0.71 FGFR1 (0.40) CA12ALDH1A1CA2CA9CA14
SCHEMBL4951509 0.70 PRKCI (0.44) CA12ALDH1A1CA9TDP1CDC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103570630-A Heterocyclic nitrogen derivative and application thereof in medicines GUANGDONG HEC PHARMACEUTICAL 2014-02-12 CN disclosed