Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Benzophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzophenone SCHEMBL31362043 | 1.00 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL28203167 | 0.97 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL9091604 | 0.89 | ALDH1A1 (0.93) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL30537001 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL6061130 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL28491203 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL30536983 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL1074283 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL28180817 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 | |
| Benzophenone SCHEMBL17745 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AMAPTSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596570-A | Oxysqualene cyclase as protein targets for anticancer therapy | UNIV MISSOURI | 2014-02-19 | — | — | CN | claimed |
| CN-103596570-B | Oxysqualene cyclase as protein targets for anticancer therapy | 密苏里大学管委会 | 2018-02-16 | — | — | CN | disclosed |
| CN-103596570-A | Oxysqualene cyclase as protein targets for anticancer therapy | UNIV MISSOURI | 2014-02-19 | — | — | CN | disclosed |