SCHEMBL27944446

SCHEMBL27944446

Oc1cccc(C2COc3cc(O)cc(O)c3C2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.48
ALOX15B O15296 2/20 0.48
ALOX12 P18054 2/20 0.48
ESR1 P03372 1/20 0.48
ESR2 Q92731 1/20 0.48
TTR P02766 1/20 0.48
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
PTGS1 P23219 3/20 0.45
PTGS2 P35354 2/20 0.45
CYP3A4 P08684 2/20 0.45
SYNJ2 O15056 1/20 0.45
BACE1 P56817 6/20 0.43
KDM4E B2RXH2 5/20 0.43
GAA P10253 3/20 0.43
HSD17B10 Q99714 3/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPT P10636 3/20 0.43
APEX1 P27695 3/20 0.43
RECQL P46063 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3955755 0.99 ALOX15 (0.47) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL2070504 0.88 ESR1 (0.50) ALOX15ALOX15BALOX12ESR1ESR2
Hydrochloric Acid SCHEMBL3957598 0.87 ESR1 (0.49) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL29391808 0.84 ESR1 (0.63) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL26078543 0.84 ESR1 (0.63) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL3954415 0.84 ESR1 (0.63) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL6944038 0.84 ESR1 (0.63) ALOX15ALOX15BALOX12ESR1ESR2
Hydrochloric Acid SCHEMBL4294837 0.82 ESR1 (0.61) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL13923917 0.80 ALOX15 (0.53) ALOX15ALOX15BALOX12ESR1ESR2
SCHEMBL19236383 0.79 ESR1 (0.75) ALOX15ALOX15BALOX12ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102503924-B Flavane (isoflavane) urease inhibitor and synthesis and use thereof UNIV JISHOU 2014-04-02 CN disclosed