Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 8/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207986 | 0.76 | ALDH1A1 (0.38) | ALDH1A1TNFPDE4APDE4BPDE4C | |
| SCHEMBL28358769 | 0.76 | KCNJ1 (0.45) | — | |
| SCHEMBL28170860 | 0.76 | MAPT (0.47) | L3MBTL1POLBKDM4EROCK2ROCK1 | |
| SCHEMBL27864179 | 0.75 | MAPT (0.44) | ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL10447571 | 0.75 | UTS2R (0.54) | ALDH1A1HSD17B10L3MBTL1TNFPDE4A | |
| SCHEMBL8242699 | 0.75 | UTS2R (0.54) | ALDH1A1HSD17B10L3MBTL1TNFPDE4A | |
| SCHEMBL27770762 | 0.74 | MAPT (0.46) | L3MBTL1ROCK2ROCK1MAPTLMNA | |
| SCHEMBL6693021 | 0.73 | TNF (0.70) | ALDH1A1HSD17B10L3MBTL1TNFPDE4A | |
| SCHEMBL10319232 | 0.73 | UTS2R (0.56) | ALDH1A1HSD17B10L3MBTL1TNFPDE4A | |
| SCHEMBL10318216 | 0.73 | UTS2R (0.56) | ALDH1A1HSD17B10L3MBTL1TNFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103429593-A | Imidazo pyrazines | HOFFMANN LA ROCHE | 2013-12-04 | — | — | CN | disclosed |