Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 7/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28763014 | 0.85 | ADRB2 (0.43) | MAPTKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL28136985 | 0.84 | SLC6A2 (0.41) | KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL28076445 | 0.84 | ALDH1A1 (0.40) | LMNAROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL28830732 | 0.84 | PSEN1 (0.44) | MAPTLMNASCN4ASMN1; SMN2NPSR1 | |
| SCHEMBL28170860 | 0.83 | MAPT (0.47) | MAPTKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL12682063 | 0.83 | CYP1A2 (0.50) | KMT2ASCN4ACYP1A2CYP2D6PKM | |
| SCHEMBL28041869 | 0.81 | ALDH1A1 (0.43) | MAPTKMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL28094567 | 0.79 | DPP4 (0.39) | MAPT | |
| SCHEMBL7100081 | 0.77 | SCN4A (0.52) | KMT2ASCN4ACYP1A2CYP2D6PKM | |
| SCHEMBL22502128 | 0.77 | SCN4A (0.52) | KMT2ASCN4ACYP1A2CYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103896831-A | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators | ABBVIE DEUTSCHLAND | 2014-07-02 | — | — | CN | disclosed |
| CN-101903349-B | 4- (4-pyridinyl) -benzamides and their use as ROCK activity modulators | ABBOTT GMBH & CO KG | 2014-01-08 | — | — | CN | disclosed |
| CN-103429593-A | Imidazo pyrazines | HOFFMANN LA ROCHE | 2013-12-04 | — | — | CN | disclosed |
| CN-101646427-B | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2013-06-12 | — | — | CN | disclosed |
| CN-101790526-A | 5-heteroaryl substituted indazoles as kinase inhibitors | ABBOTT GMBH & CO KG | 2010-07-28 | — | — | CN | disclosed |
| CN-101646427-A | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2010-02-10 | — | — | CN | disclosed |