Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL3303345 | 0.98 | GSR (0.71) | GSRSMN1; SMN2ARG2ARG1RNPEP | |
| Lysine SCHEMBL4435147 | 0.98 | GSR (0.71) | GSRSMN1; SMN2ARG2ARG1RNPEP | |
| Lysine SCHEMBL11175666 | 0.97 | GSR (0.69) | GSRSMN1; SMN2ARG2ARG1RNPEP | |
| Ornithine SCHEMBL3793499 | 0.93 | GSR (0.62) | GSRSMN1; SMN2ARG2ARG1NOS1 | |
| Ornithine SCHEMBL11171112 | 0.91 | GSR (0.60) | GSRSMN1; SMN2ARG2ARG1NOS1 | |
| Lysine SCHEMBL31679370 | 0.85 | GSR (0.80) | GSRARG2ARG1RNPEPNOS1 | |
| Lysine SCHEMBL1425217 | 0.85 | GSR (0.80) | GSRARG2ARG1RNPEPNOS1 | |
| Lysine SCHEMBL20952564 | 0.85 | GSR (0.80) | GSRARG2ARG1RNPEPNOS1 | |
| Lysine SCHEMBL1425215 | 0.85 | GSR (0.80) | GSRARG2ARG1RNPEPNOS1 | |
| Lysine SCHEMBL2589784 | 0.85 | GSR (0.80) | GSRARG2ARG1RNPEPNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103462947-B | Calcium-zinc gluconate granule and method for making thereof | GUIZHOU VIGOUR PHARMACEUTICAL CO., LTD. (CN) | 2015-09-16 | — | — | CN | disclosed |
| CN-103462947-A | Calcium zinc gluconate granules and preparation method thereof | GUIZHOU VIGOUR PHARMACEUTICAL CO LTD | 2013-12-25 | — | — | CN | disclosed |