Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Ornithine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ornithine SCHEMBL11171112 | 0.98 | GSR (0.60) | GSRSMN1; SMN2CYP1A2GRM8GRM6 | |
| Lysine SCHEMBL4435147 | 0.95 | GSR (0.71) | GSRSMN1; SMN2CYP1A2GRM8GRM6 | |
| Lysine SCHEMBL3303345 | 0.95 | GSR (0.71) | GSRSMN1; SMN2CYP1A2GRM8GRM6 | |
| Lysine SCHEMBL27946776 | 0.93 | GSR (0.69) | GSRSMN1; SMN2CYP1A2GRM8GRM6 | |
| Lysine SCHEMBL11175666 | 0.93 | GSR (0.69) | GSRSMN1; SMN2CYP1A2GRM8GRM6 | |
| Aspartic Acid SCHEMBL755884 | 0.86 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Ornithine Aketoglutarate SCHEMBL361184 | 0.86 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL28321586 | 0.86 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Aspartic Acid SCHEMBL8919110 | 0.86 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Ornithine SCHEMBL361185 | 0.86 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761377-B | L-ornithine composite salt and preparation method and application thereof | 武汉远大弘元股份有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-114761377-A | L-ornithine composite salt and preparation method and application thereof | 武汉远大弘元股份有限公司 | 2022-07-15 | — | — | CN | claimed |
| WO-2021104432-A1 | L-ORNITHINE COMPOSITE SALT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 武汉远大弘元股份有限公司 | 2021-06-03 | — | — | WO | claimed |
| CN-114761377-B | L-ornithine composite salt and preparation method and application thereof | 武汉远大弘元股份有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-114761377-A | L-ornithine composite salt and preparation method and application thereof | 武汉远大弘元股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| WO-2021104432-A1 | L-ORNITHINE COMPOSITE SALT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 武汉远大弘元股份有限公司 | 2021-06-03 | — | — | WO | disclosed |
| CN-102924311-B | Preparation method of L-aspartate-L-ornithine salt | BEIJING SIHUAN PHARM CO LTD | 2014-12-24 | — | — | CN | disclosed |
| CN-102924311-A | Preparation method of L-aspartate-L-ornithine salt | BEIJING SIHUAN PHARM CO LTD | 2013-02-13 | — | — | CN | disclosed |
| US-7772280-B2 | Crystals of L-ornithine and process for producing the same | KYOWA HAKKO BIO CO., LTD. (JP) | 2010-08-10 | — | — | US | disclosed |
| US-20090082594-A1 | CRYSTALS OF L-ORNITHINE AND PROCESS FOR PRODUCING THE SAME | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |