Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677506 | 0.90 | KMT2A (0.45) | KMT2AMEN1CYP2D6ITGB3ITGA2B | |
| SCHEMBL407286 | 0.78 | KMT2A (0.53) | KMT2AMEN1CYP2D6 | |
| SCHEMBL27673919 | 0.78 | ATM (0.48) | — | |
| SCHEMBL4629627 | 0.78 | MC4R (0.50) | KMT2AJAK3 | |
| Hydrochloric Acid SCHEMBL440964 | 0.77 | KMT2A (0.56) | KMT2AMEN1CYP2D6 | |
| SCHEMBL27945346 | 0.77 | HPGD (0.50) | — | |
| SCHEMBL1318504 | 0.71 | HPGD (0.60) | KMT2AJAK3MAPTMEN1 | |
| SCHEMBL14505992 | 0.71 | HPGD (0.60) | KMT2AJAK3MAPTMEN1 | |
| SCHEMBL408318 | 0.71 | KMT2A (0.66) | KMT2AMEN1CYP2D6 | |
| Hydrochloric Acid SCHEMBL1320464 | 0.70 | HPGD (0.58) | KMT2AJAK3MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130967-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |
| CN-103649076-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-09 | — | — | CN | disclosed |
| CN-103649076-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2014-03-19 | — | — | CN | disclosed |
| CN-103492377-A | Triazolopyridine compounds as PIM kinase inhibitors | ARRAY BIOPHARMA INC | 2014-01-01 | — | — | CN | disclosed |