Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724213 | 0.91 | CHRNB2 (0.50) | HTR2AHTR2CKCNH2CHRNB2CHRNA4 | |
| SCHEMBL13724266 | 0.82 | HTR2A (0.48) | HTR2AHTR2CKCNH2CHRNB2CHRNA4 | |
| SCHEMBL25044094 | 0.78 | CHRNB2 (0.44) | HTR2AHTR2CKCNH2CHRNB2CHRNA4 | |
| SCHEMBL6173955 | 0.73 | IKBKB (0.44) | HTR2AHTR2CKCNH2IKBKBCHUK | |
| SCHEMBL171390 | 0.72 | CHEK1 (0.57) | HTR2AHTR2CKCNH2CHEK1CCNA2 | |
| SCHEMBL14320456 | 0.72 | IKBKB (0.44) | HTR2ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL2892542 | 0.72 | CSF1R (0.50) | HTR2AHTR2CKCNH2CHRNB2CHRNA4 | |
| SCHEMBL3399446 | 0.72 | KCNH2 (0.55) | HTR2AHTR2CKCNH2HTR3AHPGDS | |
| SCHEMBL21425192 | 0.71 | DRD2 (0.60) | HTR2AHTR2CKCNH2CHEK1CCNA2 | |
| SCHEMBL22555632 | 0.71 | USP30 (0.51) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | disclosed |