Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936131 | 0.93 | MRGPRX4 (0.37) | MEN1NPC1RAB9AKMT2APTGES2 | |
| SCHEMBL27936040 | 0.86 | ITK (0.33) | PTGES2MAOBMAOAHTTCYP3A4 | |
| SCHEMBL28807365 | 0.84 | PTGER1 (0.40) | PTGES2P4HBHTTCYP3A4CYP2D6 | |
| SCHEMBL27936024 | 0.84 | PPARG (0.39) | MEN1NPC1RAB9AKMT2ASRD5A2 | |
| SCHEMBL12096810 | 0.83 | POLB (0.41) | PTGES2CPT2CPT1ACPT1BIDH1 | |
| SCHEMBL28810371 | 0.83 | MEN1 (0.36) | MEN1NPC1RAB9AKMT2AMAOB | |
| SCHEMBL28947517 | 0.81 | HTT (0.33) | MEN1KMT2AMAOBMAOAHTT | |
| Piperazine SCHEMBL27950239 | 0.80 | PPARG (0.36) | MEN1NPC1RAB9AKMT2AMAOB | |
| SCHEMBL28947331 | 0.79 | MAPT (0.36) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL27936059 | 0.78 | MEN1 (0.36) | MEN1NPC1RAB9AKMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | claimed |
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |