Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.36 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 5/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936024 | 0.95 | PPARG (0.39) | PPARGPPARARORCPPARDMEN1 | |
| SCHEMBL28810371 | 0.89 | MEN1 (0.36) | PPARGRORCMAOBP4HBMEN1 | |
| SCHEMBL27884360 | 0.89 | PPARG (0.38) | PPARGPPARARORCPPARDMAOB | |
| SCHEMBL27950252 | 0.89 | PPARG (0.38) | PPARGPPARARORCPPARDMEN1 | |
| SCHEMBL27936027 | 0.88 | PPARG (0.39) | PPARGPPARARORCPPARDNLRP3 | |
| SCHEMBL27936050 | 0.87 | PPARG (0.37) | PPARGPPARARORCPPARDALDH1A1 | |
| SCHEMBL28807363 | 0.86 | PPARG (0.35) | PPARGPPARARORCPPARDMAOB | |
| SCHEMBL27950245 | 0.86 | PPARG (0.35) | PPARGPPARAPPARD | |
| SCHEMBL27936025 | 0.86 | PPARG (0.36) | PPARGPPARARORCPPARDP4HB | |
| SCHEMBL27936028 | 0.85 | RXRA (0.36) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |