Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.37 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28129051 | 0.89 | TLR8 (0.37) | DHODHEDNRBEDNRAADORA1TLR8 | |
| SCHEMBL10325963 | 0.86 | TLR8 (0.55) | PTPN1TLR8TLR7 | |
| SCHEMBL27936568 | 0.85 | TLR8 (0.38) | DHFRTLR8TLR7 | |
| SCHEMBL27936566 | 0.83 | MAP4K4 (0.40) | LRRK2MAP4K4TLR8TLR7EGLN1 | |
| SCHEMBL27950589 | 0.82 | PPARA (0.40) | PPARGPPARATLR8TLR7 | |
| SCHEMBL28129049 | 0.81 | PRKAG1 (0.45) | MAP4K4TLR8TLR7IKBKB | |
| SCHEMBL27936502 | 0.81 | ALDH1A1 (0.44) | DHODHTLR8TLR7EGLN1IKBKB | |
| SCHEMBL27936503 | 0.81 | DPP4 (0.39) | TLR8TLR7 | |
| SCHEMBL27936501 | 0.80 | BACE1 (0.41) | DHODHPPARGPPARA | |
| SCHEMBL27936557 | 0.79 | SCN9A (0.39) | DHODHMAP4K4TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106749023-A | As the substituted benzazepine of toll-like receptor conditioning agent | 帆德制药股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-103562186-B | Substituted benzazepines as modulators of TOLL-like receptors | 帆德制药股份有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-103562186-A | Substituted benzazepines as modulators of TOLL-like receptors | VENTIRX PHARMACEUTICALS INC | 2014-02-05 | — | — | CN | disclosed |