Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9108031 | 0.89 | LMNA (0.57) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL979873 | 0.89 | LMNA (0.57) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL27316941 | 0.89 | LMNA (0.57) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL31544298 | 0.87 | LMNA (0.55) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL27480900 | 0.87 | LMNA (0.55) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL27469609 | 0.87 | LMNA (0.55) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL27604552 | 0.83 | LMNA (0.48) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL30469495 | 0.83 | LMNA (0.48) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL27521459 | 0.81 | LMNA (0.47) | LMNAPDE4AL3MBTL1TDP1USP2 | |
| SCHEMBL9651828 | 0.75 | PDE4A (0.58) | LMNAPDE4AL3MBTL1TDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103635191-A | Small molecule RNASE inhibitors and methods of use | UNIV ROCHESTER | 2014-03-12 | — | — | CN | disclosed |
| CN-103635193-A | Small molecule RNase inhibitors and methods of use | UNIV ROCHESTER | 2014-03-12 | — | — | CN | disclosed |