Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28065973 | 0.87 | FNTA (0.35) | LMNACYP3A4GABRA1TSHRGABRG2 | |
| Morpholine SCHEMBL28086483 | 0.86 | MEN1 (0.39) | — | |
| SCHEMBL126225 | 0.85 | — | — | |
| Water SCHEMBL3913449 | 0.83 | — | — | |
| SCHEMBL11876704 | 0.83 | — | — | |
| SCHEMBL3280242 | 0.83 | — | — | |
| SCHEMBL27572660 | 0.83 | — | — | |
| Ammonia Solution, Strong SCHEMBL3497099 | 0.83 | — | — | |
| Sulfuric Acid SCHEMBL8718734 | 0.83 | CA5A (0.35) | TSHRFNTAFNTB | |
| Ethylene Glycol SCHEMBL20360050 | 0.83 | TSHR (0.35) | TSHRFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103638779-B | A kind of renewable organic amine fume desulfurizing agent and preparation method thereof | HEFEI UNIVERSITY OF TECHNOLOGY (CN) | 2015-08-12 | — | — | CN | disclosed |
| CN-103638779-A | Renewable organic amine flue gas desulfurization agent and preparation method thereof | UNIV HEFEI TECHNOLOGY | 2014-03-19 | — | — | CN | disclosed |