Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27952191 | 0.87 | LMNA (0.33) | FNTAFNTBLMNATSHRCYP3A4 | |
| SCHEMBL710961 | 0.87 | — | — | |
| SCHEMBL22441053 | 0.84 | FNTA (0.40) | FNTAFNTBLMNATSHRKDM4E | |
| Hydrochloric Acid SCHEMBL701819 | 0.84 | FNTA (0.40) | FNTAFNTBLMNATSHRKDM4E | |
| SCHEMBL28237869 | 0.84 | FNTA (0.40) | FNTAFNTBLMNATSHRKDM4E | |
| Methylamine SCHEMBL28165900 | 0.80 | CA1 (0.39) | FNTAFNTBLMNATSHRKDM4E | |
| SCHEMBL445778 | 0.80 | FNTA (0.44) | FNTAFNTBLMNATSHRKDM4E | |
| Piperazine SCHEMBL27943855 | 0.79 | CA1 (0.50) | FNTAFNTBTSHRCA1CA2 | |
| SCHEMBL20275856 | 0.78 | FNTA (0.47) | FNTAFNTBLMNATSHRKDM4E | |
| 1,4-Butanediol SCHEMBL16468151 | 0.78 | FNTA (0.47) | FNTAFNTBLMNATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105498504-A | Iron ore agglomeration sintering tail gas purifying device and purifying method as well as application thereof | TONGGUAN SMELTING BRANCH OF TONGLING NONFERROUS METALS GROUP CO LTD | 2016-04-20 | — | — | CN | disclosed |