Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27651306 | 0.84 | HCAR2 (0.40) | LMNAHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL2533147 | 0.80 | ALDH1A1 (0.60) | LMNAGFERCASP6MAPTALDH1A1 | |
| SCHEMBL11352178 | 0.79 | BTK (0.38) | LMNAGFERCASP6MAPTALDH1A1 | |
| SCHEMBL23777655 | 0.79 | NOTUM (0.54) | LMNAHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL6846616 | 0.77 | MEN1 (0.47) | LMNAMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4081817 | 0.77 | HCAR2 (0.56) | LMNAHCAR2MAPTALDH1A1CYP3A4 | |
| SCHEMBL27741480 | 0.76 | SMN1; SMN2 (0.46) | LMNAMAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6844667 | 0.75 | ALDH1A1 (0.57) | LMNAMAPTALDH1A1CYP3A4GAA | |
| SCHEMBL19951454 | 0.74 | CYP3A4 (0.49) | LMNAHCAR2MAPTALDH1A1CYP3A4 | |
| SCHEMBL10126855 | 0.74 | KDM4E (0.61) | GFERMAPTALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |