Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | GCGR | P47871 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorobenzene SCHEMBL28347863 | 0.82 | HIF1A (0.54) | HIF1AEGLN1GCGR | |
| SCHEMBL27957411 | 0.82 | EGLN1 (0.66) | HIF1AEGLN1GCGR | |
| SCHEMBL27957409 | 0.80 | HIF1A (0.46) | HIF1AEGLN1GCGRMAP4K4 | |
| SCHEMBL486067 | 0.80 | KMO (0.59) | EGLN1MAP4K4CHEK2 | |
| SCHEMBL28810955 | 0.77 | ROCK2 (0.49) | GCGR | |
| Fluorobenzene SCHEMBL28344624 | 0.76 | HIF1A (0.50) | HIF1AEGLN1GCGR | |
| SCHEMBL16892862 | 0.75 | ESR2 (0.46) | MAP4K4CHEK2 | |
| SCHEMBL13555876 | 0.74 | MAP4K4 (0.56) | MAP4K4 | |
| SCHEMBL13555895 | 0.73 | MAP4K4 (0.56) | GCGRMAP4K4 | |
| SCHEMBL28347862 | 0.73 | HIF1A (0.83) | HIF1AGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717214-A | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer | AKEBIA THERAPEUTICS INC | 2014-04-09 | — | — | CN | claimed |