Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763530 | 0.85 | LMNA (0.62) | MAPTALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL25493925 | 0.85 | HPGD (0.61) | MAPTALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL40110 | 0.83 | HPGD (0.62) | MAPTALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL27249081 | 0.83 | LMNA (0.64) | MAPTALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL11736626 | 0.82 | MAPT (0.76) | MAPTALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL40490 | 0.82 | IP6K1 (0.68) | MAPTALDH1A1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL44878 | 0.82 | SIRT6 (0.79) | MAPTALDH1A1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL340455 | 0.81 | MAPT (0.78) | MAPTALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL20509684 | 0.80 | SIRT6 (0.81) | MAPTALDH1A1MAPK1HTTLMNA | |
| SCHEMBL268283 | 0.79 | MAPT (0.61) | MAPTALDH1A1HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103772374-B | A kind of heterocyclic compound and application thereof | SHAANXI SCIENCE AND ENGINEERING COLLEGE (CN) | 2016-04-06 | — | — | CN | disclosed |
| CN-103755695-B | A kind of amides and application thereof with anti-tumor activity | SHAANXI SCIENCE AND ENGINEERING COLLEGE (CN) | 2016-04-06 | — | — | CN | disclosed |
| CN-103772374-A | Novel heterocyclic compound and application thereof | UNIV SHAANXI TECHNOLOGY | 2014-05-07 | — | — | CN | disclosed |
| CN-103755695-A | Amide compounds with antitumor activity and application of amide compounds | UNIV SHAANXI TECHNOLOGY | 2014-04-30 | — | — | CN | disclosed |