Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HPD | P32754 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493011 | 0.84 | ALDH1A1 (0.54) | ALDH1A1NPC1MAPK1RAB9AGLA | |
| SCHEMBL700691 | 0.79 | NPC1 (0.56) | ALDH1A1NPC1MAPK1RAB9AGLA | |
| SCHEMBL8492671 | 0.78 | NPC1 (0.51) | ALDH1A1NPC1MAPK1RAB9AGLA | |
| SCHEMBL27960937 | 0.78 | TDP1 (0.42) | ALDH1A1NPSR1HPGDMAPTLMNA | |
| SCHEMBL2389381 | 0.76 | CFTR (0.48) | ALDH1A1NPC1MAPK1RAB9AGLA | |
| SCHEMBL30959714 | 0.74 | CFTR (0.60) | ALDH1A1MAPK1HPDMAPTTDP1 | |
| SCHEMBL29115638 | 0.74 | ALDH1A1 (0.48) | ALDH1A1NPC1MAPK1RAB9AGLA | |
| SCHEMBL1450704 | 0.74 | CFTR (0.60) | ALDH1A1MAPK1HPDMAPTTDP1 | |
| SCHEMBL8493040 | 0.73 | ALDH1A1 (0.50) | ALDH1A1NPC1MAPK1RAB9AGLA | |
| SCHEMBL27807012 | 0.72 | TDP1 (0.41) | ALDH1A1RAB9AHTTMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103923072-A | Substituted Indazole Derivatives Active As Kinase Inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2014-07-16 | — | — | CN | disclosed |
| CN-101754956-B | Substituted indazole derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2014-04-23 | — | — | CN | disclosed |