Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.64 |
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | HTR2B | P41595 | 3/20 | 0.64 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.64 |
| ▸ | HTR2A | P28223 | 3/20 | 0.64 |
| ▸ | HTR2C | P28335 | 3/20 | 0.64 |
| ▸ | HTR6 | P50406 | 3/20 | 0.64 |
| ▸ | SCN1A | P35498 | 2/20 | 0.64 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.64 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.64 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oleic Acid SCHEMBL2796167 | 1.00 | ADRB2 (0.64) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| Stearic Acid SCHEMBL11025256 | 0.94 | ADRB2 (0.71) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| Propranolol SCHEMBL7770896 | 0.94 | ADRB2 (0.71) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| Propranolol SCHEMBL10494989 | 0.89 | ADRB2 (0.69) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL2796170 | 0.84 | NR2E1 (0.54) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| Propranolol SCHEMBL5566676 | 0.83 | CYP2D6 (0.83) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| Propranolol SCHEMBL9715887 | 0.82 | ADRB2 (0.80) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL11097608 | 0.82 | ADRB2 (0.63) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| Propranolol SCHEMBL28921627 | 0.81 | CYP2D6 (0.88) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL10605795 | 0.81 | ADRB2 (0.64) | ADRB2ADRB1SIGMAR1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220047604-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | HORIZON ORPHAN LLC | 2022-02-17 | — | — | US | disclosed |
| US-10987357-B2 | Aerosolized fluoroquinolones and uses thereof | Horizon Orphan, LLC (US) | 2021-04-27 | — | — | US | disclosed |
| US-20160279138-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | RAPTOR PHARMACEUTICALS, INC. (US) | 2016-09-29 | — | — | US | disclosed |
| US-20140066441-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-8546423-B2 | Aerosolized fluoroquinolones and uses thereof | MPEX PHARMACEUTICALS, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8524735-B2 | Aerosolized fluoroquinolones and uses thereof | MPEX PHARMACEUTICALS, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524734-B2 | Aerosolized fluoroquinolones and uses thereof | MPEX PHARMACEUTICALS, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| EP-2594272-A2 | Aerosolized fluoroquinolones and uses thereof | MPEX PHARMACEUTICALS, INC. (US) | 2013-05-22 | — | — | EP | disclosed |
| US-8357696-B2 | Aerosolized fluoroquinolones and uses thereof | MPEX PHARMACEUTICALS, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-7838532-B2 | Aerosolized fluoroquinolones and uses thereof | MPEX PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-20100166673-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100158957-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100037890-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100040560-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| EP-1901749-A2 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007095156-A2 | TASTE MASKING OF AEROSOLIZED FLUOROQUINOLONES | MPEX PHARMACEUTICALS, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20060276483-A1 | Aerosolized fluoroquinolones and uses thereof | HORIZON THERAPEUTICS U.S. HOLDING LLC | 2006-12-07 | — | — | US | disclosed |
| WO-2006125132-A2 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | MPEX PHARMACEUTICALS, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| US-4863952-A | Method of promoting percutaneous drug absorption with 2-pyrrolidin-2-one 5-carboxylic acids and esters thereof | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100166673-A1 | AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF | NQO2, IFNG, RECQL | ADRB2 1592/4885ADRB1 1483/4885SIGMAR1 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.