Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27962862 | 0.88 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL7380449 | 0.84 | CNR2 (0.55) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL27905855 | 0.82 | GABRG2 (0.50) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL31623719 | 0.82 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL30022454 | 0.81 | CHRM2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL13696680 | 0.81 | CHRM2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL27905854 | 0.81 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL28583285 | 0.80 | KDM4E (0.61) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL27938900 | 0.79 | CHRM2 (0.43) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL27905863 | 0.78 | CHRM2 (0.49) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103880841-B | Hdac inhibitor containing β-carboline-3-acyl hydrazono-and its production and use | NANTONG UNIVERSITY (CN) | 2016-04-13 | — | — | CN | disclosed |
| CN-103880841-A | HDAC (histone deacetylase) inhibitor containing beta- carboline-3-acryl hydrazono as well as preparation method and application thereof | UNIV NANTONG | 2014-06-25 | — | — | CN | disclosed |