Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | AKR1B10 | O60218 | 5/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.61 |
| ▸ | CA4 | P22748 | 2/20 | 0.61 |
| ▸ | CA6 | P23280 | 2/20 | 0.61 |
| ▸ | CA5A | P35218 | 2/20 | 0.61 |
| ▸ | CA7 | P43166 | 2/20 | 0.61 |
| ▸ | CA9 | Q16790 | 2/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.61 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13715309 | 0.86 | LMNA (0.57) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL11837322 | 0.84 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL11837318 | 0.84 | LMNA (0.67) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL4469020 | 0.83 | LMNA (0.65) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL2159521 | 0.83 | LMNA (0.65) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL23425096 | 0.83 | LMNA (0.65) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL4469023 | 0.83 | LMNA (0.65) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL2159523 | 0.83 | LMNA (0.65) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL2152829 | 0.83 | L3MBTL1 (0.66) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL29641956 | 0.81 | LMNA (0.82) | LMNAAKR1B10AKR1B1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103910676-B | A kind of synthetic method of polysubstituted tetrahydro isoquinoline derivative | EAST CHINA NORMAL UNIVERSITY (CN) | 2015-11-18 | — | — | CN | claimed |
| CN-103910676-A | Synthetic method of polysubstituted tetrahydroisoquinoline derivative | UNIV EAST CHINA NORMAL | 2014-07-09 | — | — | CN | claimed |
| CN-103910676-B | A kind of synthetic method of polysubstituted tetrahydro isoquinoline derivative | EAST CHINA NORMAL UNIVERSITY (CN) | 2015-11-18 | — | — | CN | disclosed |
| CN-103910676-A | Synthetic method of polysubstituted tetrahydroisoquinoline derivative | UNIV EAST CHINA NORMAL | 2014-07-09 | — | — | CN | disclosed |