Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27969863 | 0.99 | PARP1 (0.46) | PARP1RAB9APARP2KMT2AMEN1 | |
| SCHEMBL27969895 | 0.87 | PARP1 (0.44) | PARP1RAB9APARP2KMT2AMEN1 | |
| SCHEMBL27969891 | 0.84 | P2RX7 (0.51) | PARP1KMT2AMEN1CNR1 | |
| SCHEMBL27969982 | 0.83 | P2RX7 (0.53) | PARP1KMT2AMEN1CNR1 | |
| SCHEMBL9996739 | 0.73 | TP53 (0.47) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6175358 | 0.73 | CD38 (0.48) | PARP1CNR1 | |
| SCHEMBL27969862 | 0.73 | CNR1 (0.43) | PARP1PARP2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27969977 | 0.72 | P2RX7 (0.48) | PARP1PARP2KMT2AMEN1CNR1 | |
| SCHEMBL4707109 | 0.72 | TP53 (0.49) | RAB9AKMT2AMEN1 | |
| SCHEMBL30100415 | 0.72 | CD38 (0.44) | PARP1KMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102046240-B | Novel P2X7R antagonists and their use | AFFECTIS PHARMACEUTICALS AG | 2014-06-25 | — | — | CN | disclosed |