Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CEL | P19835 | 2/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27969863 | 0.88 | PARP1 (0.46) | PARP1PARP2CNR2CNR1RAB9A | |
| SCHEMBL27969898 | 0.87 | PARP1 (0.44) | PARP1PARP2CNR1RAB9AKMT2A | |
| SCHEMBL27969862 | 0.86 | CNR1 (0.43) | PARP1PARP2CNR2CNR1KMT2A | |
| SCHEMBL27969977 | 0.85 | P2RX7 (0.48) | PARP1PARP2CNR2CNR1KMT2A | |
| SCHEMBL6175349 | 0.76 | TP53 (0.43) | RAB9AKMT2AMEN1CELSIRT2 | |
| SCHEMBL30100457 | 0.75 | HMGB1 (0.44) | PARP1RAB9AKMT2AMEN1CEL | |
| SCHEMBL27969982 | 0.74 | P2RX7 (0.53) | PARP1CNR2CNR1KMT2AMEN1 | |
| SCHEMBL27969891 | 0.72 | P2RX7 (0.51) | PARP1CNR2CNR1KMT2AMEN1 | |
| SCHEMBL1020350 | 0.70 | IL1B (0.53) | CNR2CNR1RAB9AKMT2AIL1B | |
| SCHEMBL1021986 | 0.70 | IL1B (0.53) | CNR2CNR1RAB9AKMT2AIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102046240-B | Novel P2X7R antagonists and their use | AFFECTIS PHARMACEUTICALS AG | 2014-06-25 | — | — | CN | disclosed |