Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2401224 | 0.87 | AKR1C3 (0.54) | TRPC6MAPTMAPK1ALDH1A1POLB | |
| SCHEMBL13012631 | 0.86 | CKS1B (0.47) | TRPC6MAPTCKS1BSKP1SKP2 | |
| SCHEMBL7706626 | 0.85 | TRPC6 (0.47) | TRPC6CASP6GFER | |
| SCHEMBL25972045 | 0.84 | MAPT (0.53) | TRPC6MAPTMAPK1MEN1KMT2A | |
| SCHEMBL29544175 | 0.84 | CASP6 (0.64) | TRPC6MAPTSYKMEN1KMT2A | |
| SCHEMBL2450248 | 0.84 | CASP6 (0.64) | TRPC6MAPTSYKMEN1KMT2A | |
| SCHEMBL19705665 | 0.83 | TRPC6 (0.45) | TRPC6MAPTCASP6GFER | |
| SCHEMBL29600699 | 0.82 | TRPC6 (0.52) | TRPC6MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL1393850 | 0.82 | TRPC6 (0.52) | TRPC6MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL19711805 | 0.81 | TRPC6 (0.49) | TRPC6CASP6GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102369187-B | N- (hetero) aryl, 2- (hetero) aryl substituted acetamides as WNT signal modulators | IRM LLC | 2014-06-04 | — | — | CN | disclosed |