Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dibenzofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibenzofuran SCHEMBL28107446 | 0.98 | KDM4E (0.52) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL28169618 | 0.84 | KDM4E (0.65) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL28153003 | 0.83 | SMN1; SMN2 (0.50) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL28239307 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL9868133 | 0.82 | MAPT (0.68) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL8207 | 0.82 | MAPT (0.68) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL29635704 | 0.82 | MAPT (0.68) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL7810840 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| Dibenzofuran SCHEMBL9651343 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL24307195 | 0.79 | MAPT (0.65) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103890617-B | The manufacture method of blooming, planar luminous body and blooming | MITSUBISHI RAYON CO.,LTD. (JP) | 2016-01-06 | — | — | CN | disclosed |
| CN-103890617-A | Optical film, surface light emitting body, and method for producing optical film | MITSUBISHI RAYON CO | 2014-06-25 | — | — | CN | disclosed |