Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280302 | 0.90 | ITGB3 (0.32) | ITGB3ITGA2BCYP1A2HRH2HRH1 | |
| SCHEMBL279648 | 0.88 | ALDH1A1 (0.40) | ITGB3ITGA2BHRH2HRH4ALDH1A1 | |
| SCHEMBL279877 | 0.86 | ALDH1A1 (0.34) | ITGB3ITGA2BALDH1A1GAA | |
| SCHEMBL280325 | 0.84 | ITGB3 (0.32) | ITGB3ITGA2BALDH1A1 | |
| SCHEMBL280450 | 0.84 | ALDH1A1 (0.48) | ITGB3ITGA2BALDH1A1 | |
| SCHEMBL12646852 | 0.83 | ITGB3 (0.43) | ITGB3ITGA2BCYP1A2HRH2HRH1 | |
| SCHEMBL14293704 | 0.82 | ALDH1A1 (0.34) | ITGB3ITGA2BALDH1A1 | |
| SCHEMBL279873 | 0.81 | ALDH1A1 (0.39) | CYP1A2HRH2HRH1HRH4ALDH1A1 | |
| SCHEMBL13763088 | 0.81 | CYP1A2 (0.34) | CYP1A2HRH2HRH1HRH4 | |
| SCHEMBL280339 | 0.81 | GAA (0.55) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7968575-B2 | Nitric oxide donors and uses thereof | RENOPHARM LTD. (IL) | 2011-06-28 | — | — | US | disclosed |
| US-7579477-B2 | Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2009-08-25 | — | — | US | disclosed |
| US-7498445-B2 | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof | RENOPHARM LTD. (IL) | 2009-03-03 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |